Blar i forfatter "Nizet, Victor"

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    • Bacterial membrane-derived vesicles attenuate vancomycin activity against methicillin-resistant staphylococcus aureus 

      Kumaraswamy, Monika; Wiull, Kamilla; Joshi, Bishnu; Sakoulas, George; Kousha, Armin; Vaaje-Kolstad, Gustav; Johannessen, Mona; Hegstad, Kristin; Nizet, Victor; Askarian, Fatemeh (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-29)
      Methicillin-resistant Staphylococcus aureus (MRSA) has evolved numerous antimicrobial resistance mechanisms and is identified as a serious public health threat by the World Health Organization and U.S. Centers for Disease Control and Prevention. The glycopeptide vancomycin (VAN) remains a cornerstone of therapy for severe MRSA infections despite increasing reports of therapeutic failure in hospitalized ...

    • Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia 

      Askarian, Fatemeh; Tsai, Chih-Ming; Cordara, Gabriele; Zurich, Raymond H.; Bjånes, Elisabet; Golten, Ole; Sørensen, Henrik Vinther; Kousha, Armin; Meier, Angela; Chikwati, Elvis Mashingaidze; Bruun, Jack-Ansgar; Ludviksen, Judith K; Choudhury, Biswa; Trieu, Desmond; Davis, Stanley; Edvardsen, Per Kristian Thorén; Mollnes, Tom Eirik; Liu, George Y.; Krengel, Ute; Conrad, Douglas J.; Vaaje-Kolstad, Gustav; Nizet, Victor (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)
      Pseudomonas aeruginosa (PA) CbpD belongs to the lytic polysaccharide monooxygenases (LPMOs), a family of enzymes that cleave chitin or related polysaccharides. Here, we demonstrate a virulence role of CbpD in PA pneumonia linked to impairment of host complement function and opsonophagocytic clearance. Following intratracheal challenge, a PA ΔCbpD mutant was more easily cleared and produced less ...

    • The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection 

      Askarian, Fatemeh; Uchiyama, Satoshi; Masson, Helen; Sørensen, Henrik Vinther; Golten, Ole; Bunæs, Anne Cathrine; Mekasha, Sophanit; Røhr, Åsmund Kjendseth; Kommedal, Eirik Garpestad; Ludviksen, Judith Anita; Arntzen, Magnus Øverlie; Schmidt, Benjamin; Zurich, Raymond H.; Van Sorge, Nina M.; Eijsink, Vincent; Krengel, Ute; Mollnes, Tom Eirik; Lewis, Nathan E.; Nizet, Victor; Vaaje-Kolstad, Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-23)
      The recently discovered lytic polysaccharide monooxygenases (LPMOs), which cleave polysaccharides by oxidation, have been associated with bacterial virulence, but supporting functional data is scarce. Here we show that CbpD, the LPMO of <i>Pseudomonas aeruginosa</i>, is a chitin-oxidizing virulence factor that promotes survival of the bacterium in human blood. The catalytic activity of CbpD was ...

    • Serine-aspartate-repeat protein D Increases Staphylococcus aureus Virulence and Survival in Blood 

      Askarian, Fatemeh; Uchiyama, Satoshi; Valderrama, J. Andrés; Ajayi, Clement; Sollid, Johanna U. E.; Van Sorge, Nina M.; Nizet, Victor; van strijp, Jos A. G.; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)
      Staphylococcus aureus expresses a panel of cell wall-anchored adhesins, including proteins belonging to the microbial surface components recognizing adhesive matrix molecule (MSCRAMM) family, exemplified by the serine-aspartate repeat protein D (SdrD), which serve key roles in colonization and infection. Deletion of sdrD from S. aureus subsp. aureus strain NCTC8325-4 attenuated bacterial survival ...

    • A staphylococcus aureus TIR domain protein virulence factor blocks TLR2-mediated NF-κB signaling 

      Askarian, Fatemeh; van Sorge, Nina; Sangvik, Maria; Beasley, Federico C; Henriksen, Jørn Remi; Sollid, Johanna U Ericson; van Strijp, Jos A. G.; Nizet, Victor; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)